Molecular Surgery for Scientists
Advanced Targeting Systems (ATS) provides a wide range of targeting tools for use in scientific research. Their technology is based around the ribosome inactivating protein, Saporin, which ATS conjugate to a variety of different antibodies against specific cell surface molecules. When used in vivo or in cell culture, the Saporin-conjugated antibody binds to its cell surface ligand, becomes internalised, and the saponin inactivates the ribosome resulting in cell death.
ATS’s products include specific lesioning agents for cholinergic basal forebrain neurons, noradrenergic and adrenergic neurons, macrophages and microglia and a pan-neuronal agent that strikes an epitope expressed on all neurons. In addition, ATS produces "second immunotoxins" (or "secondary conjugates") which allow users to convert their own targeting agents into specific cytotoxic tools. The Company also provides several neuronal and neuroendocrine antibodies.
A range of trial-size antibodies are currently available from ATS - please visit the ATS Website for further information.
Quarterly newsletters are also available, describing the latest trends and publications in the molecular neurosurgery field. Please email us if you wish to receive the ATS Quarterly newsletter or would like further information about the ATS product range.